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IL-17RA / CD217(33-320) Fc Chimera Protein, Human

IL-17RA / CD217(33-320) Fc Chimera Protein, Human

Catalog Number: UA011361 Brand: UA BIOSCIENCE
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$110 USD
$110 USD
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Product Details

Product Specification


Species Human
Synonyms CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R
Accession Q96F46-1
Amino Acid Sequence

Leu 33 - Trp 320 with hIgG1 Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)
Purity ＞95% by SDS-PAGE & SEC-HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Gaffen S L. An overview of IL-17 function and signaling[J]. Cytokine, 2008, 43(3):0-407.
2.Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
3.Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.

Background

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.
All IL-17 isoforms signal through IL-17R. Five subunits of IL-17R have been described to date, which couple to form a homo- or hetero-receptor complex. Characteristically, IL-17RA is a common subunit in all hetero-receptors. IL-17RA has unique structural-containing a SEFIR/TILL domain-and functional-requiring ACT-1 for signaling-properties, enabling Th17 cells to act as a bridge between innate and adaptive immune cells.

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SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).

RP-HPLC

The purity of IL-17RA / CD217(33-320) Protein, Fc Tag, Human is more than 95% determined by SEC-HPLC.

ELISA

Immobilized IL-17A Protein, Human (Cat. No. UA040483) at 5.0μg/mL (100μL/well) can bind IL-17 RA / CD217(33-320) Protein, Fc Tag, Human with EC50 of 0.0081-0.0.027 ng/mL.