2μg (R: reducing condition, N: non-reducing condition).
IL-17A/CTLA-8 His Tag Protein, Cynomolgus
IL-17A/CTLA-8 His Tag Protein, Cynomolgus
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$215 USD
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | Interleukin-17A, IL-17 |
| Accession | XP_005552816.1 |
| Amino Acid Sequence | |
| Expression System | HEK293 |
| Molecular Weight | 17-18 kDa,22-25 kDa and 27-28 kDa(Reducing) |
| Endotoxin | <0.1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation |
| Stability & Storage |
· 12 months from date of receipt,lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃under sterile conditions after reconstitution. · 1 week, 2 to 8℃under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Interleukin-17A (IL-17A), also known as CTLA8, is a proinflammatory cytokine belonging to the IL-17 family (which includes six members: IL-17A through IL-17F), produced by activated T cells as well as various innate and adaptive immune cells. Structurally, IL-17A exists in both glycosylated and nonglycosylated forms. Functionally, it regulates NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways, stimulates the expression of IL-6 and cyclooxygenase-2 (COX-2), and enhances nitric oxide (NO) production, thereby mediating diverse cellular processes including proliferation, differentiation, and apoptosis. Clinically, elevated IL-17 levels are strongly associated with several chronic inflammatory and autoimmune diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis, making it a key therapeutic target for inflammatory disorders.
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SDS-PAGE
SEC-HPLC
| The purity of IL-17A/CTLA-8 His Tag Protein, Cynomolgus is more than 90% determined by SEC-HPLC. |
ELISA
Immobilized IL-17A/CTLA-8 His Tag Protein, Cynomolgus (Cat. No.UA016136) at 2.0μg/mL (100μL/well) can bind Anti-Anti-IL-17A Monoclonal Antibody(Secukinumab) (Cat. No.S0B0571) with EC50 of 0.062-1.00ng/mL.
Immobilized IL-17A/CTLA-8 His Tag Protein, Cynomolgus (Cat. No.UA016136) at 2.0μg/mL (100μL/well) can bind Anti-IL-17A Monoclonal Antibody(Ixekizumab) (Cat. No.S0B0565) with EC50 of 0.97-3.00ng/mL.
Immobilized IL-17A/CTLA-8 His Tag Protein, Cynomolgus (Cat. No.UA016136) at 2.0μg/mL (100μL/well) can bind IL-17RA/CD217(33-320) Fc Chimera Protein, Human (Cat. No.UA011361) with EC50 of 1.50-3.20ng/mL.
