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IL-17 RB Fc Chimera Protein, Human

IL-17 RB Fc Chimera Protein, Human

Catalog Number: UA016039 Brand: UA BIOSCIENCE
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$215 USD
$215 USD
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Product Details

Product Specification


Species Human
Synonyms CRL4, EVI27, IL17BR
Accession Q9NRM6
Amino Acid Sequence

Arg 18 - Pro 292 with hIgG1 Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight

70-100kDa (Reducing)

Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1. Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB. (2025). Cell, 188(8), 2203-2217.e17.
2. Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation. (2025). Nature Immunology, 26, 568-580.
3: IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor. (2025). Allergy, 80(4), 965-975.

Background

IL-17RB (Interleukin-17 Receptor B), also known as IL-25R, is a type I transmembrane glycoprotein belonging to the IL-17 receptor family. It serves as the specific receptor subunit for the cytokine IL-25 (also called IL-17E) and forms a functional signaling complex with IL-17RA.

Mechanism of Action: IL-25 binds specifically to IL-17RB, which allosterically initiates the formation of a ternary complex with IL-17RA, necessary for downstream signaling events . This complex recruits the adaptor protein ACT1 and activates canonical NF-κB and MAPK pathways, leading to the production of type 2 cytokines such as IL-4, IL-5, and IL-13 . The IL-25/IL-17RB axis is a critical driver of type 2 immune responses.

Picture

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of IL-17 RB Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.

ELISA

Immobilized IL-17 RB Fc Chimera Protein, Human (Cat. No. UA016039) at 5 μg/mL (100 μL/well) can bind Human IL-25, His tag with EC50 of 0.86-1.2 ng/mL.