IL-15 Recombinant Rabbit mAb (SDT-1596-122)

Interleukin-15 (IL-15) is a pleiotropic cytokine discovered in 1994, belonging to the 4-α helix bundle family of cytokines, which also includes IL-2. It plays a critical role in the immune system, particularly in the activation, proliferation, and survival of immune cells such as T cells, natural killer (NK) cells, and NKT cells. Its unique signaling mechanisms and broad biological functions make it a critical focus in immunology and immunotherapy research. IL-15 has emerged as a promising candidate for immunotherapy, particularly in cancer treatment. Its ability to enhance NK and T cell responses without inducing activation-induced cell death (AICD) makes it a favorable alternative to IL-2. Recent advancements include the development of IL-15 superagonists like N-803, which has been approved by the FDA for treating non-muscle-invasive bladder cancer.