IL-15 Protein, Rat

Catalog Number: UA040389 Brand: UA BIOSCIENCE

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$330 USD

Size: 10μg 50μg 100μg 500μg 1mg

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Product Details

Product Specification

Species	Rat
Synonyms	Interleukin-15; IL-15;
Accession	P97604
Amino Acid Sequence	Asn49-Ser162
Expression System	E.coli
Molecular Weight	14 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 250mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Reference	J Immunother Cancer. 2022 Jan;10(1): e004104.

Background

Interleukin-15 (IL-15) is a critical cytokine that plays a significant role in the proliferation, survival, and function of immune cells, particularly natural killer (NK) cells and CD8+ T cells. In rats, IL-15 has been shown to support the development and maintenance of these immune cell populations, which are essential for immune surveillance and defense against infections and tumors.
IL-15 acts through a receptor complex composed of IL-15Rα, IL-2Rβ, and the common γ-chain (γc). This complex is crucial for high-affinity binding and signaling, which drives the expansion and activation of immune cells. Studies in rat models have demonstrated that IL-15 can enhance the cytotoxic activity of NK cells and promote the survival of memory CD8+ T cells, contributing to antitumor responses.