Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The EC50 for this effect is less than 5 ng/mL.
IL-15 Protein, Mouse
IL-15 Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-15; IL-15; |
| Accession | P48346 |
| Amino Acid Sequence | Asn49-Ser162 |
| Expression System | E.coli |
| Molecular Weight | 14 kDa (Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 2024 Nov 27. |
Background
Interleukin-15 (IL-15) is a multifunctional cytokine that plays a critical role in the development, activation, and survival of various immune cells, particularly natural killer (NK) cells and CD8+ T cells. In mice, IL-15 has been shown to promote the expansion and activation of these immune cells, which are essential for immune surveillance and defense against infections and tumors.
IL-15 acts through a receptor complex composed of IL-15Rα, IL-2Rβ, and the common γ-chain (γc). This complex is necessary for high-affinity binding and signaling, which drives the proliferation and differentiation of immune cells. Studies have demonstrated that IL-15 can enhance the cytotoxic activity of NK cells and memory CD8+ T cells, contributing to antitumor responses.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
