Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EC50 for this effect is less than 1ng/ml.
IL-11 Protein, Human
IL-11 Protein, Human
Price:
Regular price
$198.00 USD
Regular price
Sale price
$198.00 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-11; IL-11; Adipogenesis inhibitory factor; Oprelvekin; |
| Accession | P20809 |
| Amino Acid Sequence | Gly23-Leu199 |
| Expression System | E.coli |
| Molecular Weight | 22 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 200mM NaCl, pH9.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | J Leukoc Biol. 2010 Dec;88(6):1109-17. Epub 2010 Jul 7. |
Background
Interleukin-11 (IL-11) is a cytokine that belongs to the interleukin-6 (IL-6) family of cytokines. IL-11 is produced by various cell types, including stromal cells, fibroblasts, and immune cells, and plays a critical role in regulating hematopoiesis, bone metabolism, and gastrointestinal mucosal integrity. IL-11 exerts its effects through binding to the IL-11 receptor complex, leading to the activation of signaling pathways involved in cell proliferation, differentiation, and survival. IL-11 is known for its anti-inflammatory and tissue-protective properties, making it a potential therapeutic target for various inflammatory and tissue injury-related conditions.
Picture
Picture
Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
