Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF‑7 human breast cancer cells. The EC50 for this effect is 54-116 ng/mL in the presence of 14 ng/mL rhIGF-II.
IGFBP-5 Protein, Human
IGFBP-5 Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5 |
| Accession | P24593 |
| Amino Acid Sequence | Leu21-Glu272 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 35-80 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Front Endocrinol (Lausanne). 2018 Feb 20;9:53. |
Background
Insulin-like growth factor-binding protein 5 (IGFBP-5) is a member of the IGFBP family, which consists of six high-affinity binding proteins (IGFBP-1 to IGFBP-6) that regulate the bioavailability and activity of insulin-like growth factors (IGFs), namely IGF-I and IGF-II. IGFBP-5 is a multifunctional protein that not only modulates IGF signaling but also exhibits IGF-independent functions. It is widely expressed in various tissues, including bone, breast, prostate, and the cardiovascular system, and plays a critical role in cellular growth, differentiation, apoptosis, and tissue development.
IGFBP-5 is involved in various diseases, including cancer, diabetes, and cardiovascular disorders. In cancer, IGFBP-5 exhibits dual roles, acting as either a tumor suppressor or promoter depending on the cellular context. For example, it is overexpressed in aggressive glioblastoma and osteosarcoma, where it promotes tumor invasion and metastasis. Conversely, in breast cancer, IGFBP-5 can inhibit tumor growth by inducing apoptosis.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
