Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is less than 5ng/ml.
IGF-I Protein, Human
IGF-I Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | IGF-I Protein, IGF1A Protein, IGFI Protein |
| Accession | P05019 |
| Amino Acid Sequence | Gly49-Ala118 |
| Expression System | E.coli |
| Molecular Weight | 8-9kDa (Non-Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 50mM NaAc, pH6.0. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Jansen M., et al.(1983)Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature306:609-611. |
Background
Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. IGF-1 Protein binds to cell surface receptor IGF type 1 receptor, which abbreviated as "IGF1R" and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. IGF-1 Protein also mediates neuroprotective mechanism. It is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.
Picture
Picture
Bioactivity
SDS-PAGE
2μg ( N: non-reducing condition).
