IGF-I Protein, Bovine/Human
IGF-I Protein, Bovine/Human
Product Details
Product Details
Product Specification
| Species | Bovine |
| Accession | P07455 |
| Amino Acid Sequence | Gly50-Ala119 |
| Expression System | E.coli |
| Molecular Weight | 8-9kDa (Non-Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 50mM NaAc, pH6.0. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Jansen M., et al.(1983)Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature306:609-611. |
Background
Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C,IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structureto insulin. IGF-1 Protein binds to cell surface receptor IGF type 1 receptor,which abbreviated as "IGF1R" and modulates growth in many tissues,such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle,endothelium, and bone. IGF-1 Protein also mediates neuroprotective mechanism.It is produced primarily by the liver as an endocrine hormone as well as intarget tissues in a paracrine/autocrine fashion. IGF-1 consists of 70 aminoacids in a single chain with three intramolecular disulfide bridges. IGF-1 hasa molecular weight of 7649 daltons.
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Bioactivity
SDS-PAGE
