Human t-PA, His Tag

t-PA (tissue plasminogen activator) is a serine protease that hydrolyzates fibrinogen into fibrinolytic enzyme, which plays an important role in fibrinolytic system and maintenance of extracellular matrix homeostasis.t-PA can be high affinity to thrombus matrix and activate fibrinase at the site of thrombus to produce bioactive fibrinase, so as to hydrolyze fibrin， resulting in dissolving thrombus and recanalizing blood vessels without causing systemic activation of fibrinolysis and greatly reducing the risk of hemolysis. It is a specific medicine for the treatment of acute myocardial infarction and other thrombotic diseases.t-PA also exists in the central nervous system and is involved in the occurrence and development of diseases including epilepsy, cerebral ischemia and sciatic nerve injury, as well as a variety of physiological processes including brain learning and memory function, nervous system development and so on.In addition, as a cytokine, T-PA also participates in the pathogenesis of renal interstitial fibrosis through a variety of mechanisms.This product is the recombinant human t-PA protein expressed from human 293 cells (HEK293).