1 1

Human NPTX2 Protein, His Tag

Human NPTX2 Protein, His Tag

Catalog Number: S0A0214 Brand: Starter
Share:
Price:
$100 USD
$100 USD
Size:

For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details

Product Details

Product Specification


Species Human
Synonyms Neuronal pentraxin-2, NP2, Neuronal pentraxin II (NP-II)
Accession P47972
Amino Acid Sequence

Protein sequence (P47972, Gly16-Leu431, with C-His Tag) GAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL
Expression System HEK293
Molecular Weight Predicted MW: 47.4 kDa Observed MW: 55-70 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Neuronal Pentraxin 2 (NPTX2), also known as Neuronal Activity-Regulated Pentraxin (NARP), is a secreted protein predominantly expressed in neurons. It belongs to the pentraxin family and is rapidly induced by synaptic activity. Its primary function is at excitatory synapses, where it organizes the surface expression of AMPA-type glutamate receptors. By clustering these receptors, NPTX2 is crucial for strengthening synaptic connections and is a key mediator of homeostatic and experience-dependent plasticity. Dysregulation of NPTX2 is increasingly associated with various neurological disorders, including cognitive impairment, Alzheimer's disease, and schizophrenia.

Picture

SDS-PAGE

2μg（R: reducing conditions）