Human & Monkey TNF RI/TNFRSF1A OneStep ELISA Kit
Human & Monkey TNF RI/TNFRSF1A OneStep ELISA Kit
Product Details
Product Details
Product Specification
| Antigen | TNF RI |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu, Mk |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8°C as supplied. |
Kit
| Precision | Intra-assay: 3.7%； Inter-assay: 6.9% |
| Sample type | Serum; Heparin Plasma, Citrate Plasma; Cell Culture Supernatant |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 3.23 pg/mL |
| Range | 14.1 pg/mL – 900 pg/mL |
| Recovery | Serum: 87% Citrate plasma: 98% Heparin Plasma: 96% Cell Culture Supernatant: 96% |
| Assay time | 60 minutes |
| Species reactivity | Hu, Mk |
Background
Human and monkey TNF RI (TNFRSF1A) are highly homologous type I transmembrane receptors that share a conserved extracellular cysteine-rich ligand-binding domain, a transmembrane helix, and an intracellular death domain responsible for mediating NF-κB, MAPK, and apoptotic signaling upon TNF-α stimulation. Due to their structural and functional similarity, monkey TNF RI serves as an essential translational model in non-human primate preclinical studies for evaluating drug efficacy and safety, while human TNF RI is a major therapeutic target for autoimmune and inflammatory diseases, with applications including recombinant protein production, antibody development, small-molecule inhibitor screening, and structure-based drug design aimed at modulating its signaling pathways.
