Immobilized Human IGFBP-2 Protein, His Tag at 2 μg/mL (100 μL/well) can bind Human IGF-2 Protein, hFc tag (Cat. No. S0A4045) with EC50 of 3.2-3.6 ng/ml.
Human IGFBP-2 Protein, His Tag
Human IGFBP-2 Protein, His Tag
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$95 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, BP2, IBP2 |
| Accession | P18065 |
| Amino Acid Sequence | Protein sequence (P18065, Ala36-Gln325, with C-His Tag) AEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 33.1 kDa Observed MW: 33 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
PVRIG (also known as CD112R) is an immune checkpoint protein belonging to the DNAM-1/TIGIT/CD96 family. It interacts with its ligand, PVRL2 (CD112), which is expressed on antigen-presenting cells and tumor cells. PVRIG functions as a co-inhibitory receptor, primarily expressed on T cells and NK cells, and plays a critical role in modulating immune responses. By binding to PVRL2, PVRIG suppresses T-cell and NK-cell activation, contributing to immune evasion in cancers.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
