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Human IGFBP-2 Protein, His Tag

Human IGFBP-2 Protein, His Tag

Catalog Number: S0A0182 Brand: Starter
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$124.00 SGD
$124.00 SGD
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Product Details

Product Specification


Species Human
Synonyms Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, BP2, IBP2
Accession P18065
Amino Acid Sequence

Protein sequence (P18065, Ala36-Gln325, with C-His Tag) AEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ
Expression System HEK293
Molecular Weight Predicted MW: 33.1 kDa Observed MW: 33 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

PVRIG (also known as CD112R) is an immune checkpoint protein belonging to the DNAM-1/TIGIT/CD96 family. It interacts with its ligand, PVRL2 (CD112), which is expressed on antigen-presenting cells and tumor cells. PVRIG functions as a co-inhibitory receptor, primarily expressed on T cells and NK cells, and plays a critical role in modulating immune responses. By binding to PVRL2, PVRIG suppresses T-cell and NK-cell activation, contributing to immune evasion in cancers.

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Bioactivity

Immobilized Human IGFBP-2 Protein, His Tag at 2 μg/mL (100 μL/well) can bind Human IGF-2 Protein, hFc tag (Cat. No. S0A4045) with EC50 of 3.2-3.6 ng/ml.

SDS-PAGE

2μg（R: reducing conditions）