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Human Factor H-related 1/CFHR1 Protein, His Tag

Human Factor H-related 1/CFHR1 Protein, His Tag

Catalog Number: S0A6060 Brand: Starter
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Product Details

Product Specification


Species Human
Synonyms Complement factor H-related protein 1, FHR-1, H factor-like protein 1 (FHL-1, H-factor-like 1), H36, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2
Accession Q03591
Format


Capacity


Principle of Separation


Amino Acid Sequence

Protein sequence (Q03591, Glu19-Arg330, with C-His Tag) EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Expression System HEK293
Molecular Weight

Predicted MW: 37.4 kDaObserved MW: 37-45 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Reference


Background

CFHR1 (Complement Factor H-Related Protein 1) is a secreted glycoprotein belonging to the factor H protein family. It is primarily synthesized in the liver and circulates in blood plasma. CFHR1 modulates the complement system, a key part of innate immunity, by competing with factor H for C3b binding. It regulates complement activation on surfaces, influencing inflammatory responses. Dysregulation or deficiency of CFHR1 is associated with atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD).

Components


Protocol


Picture

SDS-PAGE

2μg（R: reducing conditions）