Immobilized HB-EGF Protein, Human (Cat. No. UA040500) at 5 μg/mL (100 μL/well) can bind Human EGF R Protein, hFc Tag with EC50 of 0.88-1.14 ng/ml.
Human EGF R Protein, hFc Tag
Human EGF R Protein, hFc Tag
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$100 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1, EGFR |
| Accession | P00533-1 |
| Amino Acid Sequence | Protein sequence (P00533-1, Leu25-Ser645, with C-hFc Tag) LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPS |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 95.5 kDaObserved MW: 120-130 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The Epidermal Growth Factor Receptor (EGFR) is a transmembrane tyrosine kinase receptor belonging to the ErbB family. Upon binding to its ligands such as EGF or TGF-α, EGFR undergoes homo- or hetero-dimerization, triggering autophosphorylation of intracellular tyrosine residues and activation of downstream signaling cascades including MAPK/ERK, PI3K/AKT, and JAK/STAT pathways. These regulate critical cellular processes including proliferation, survival, migration, and differentiation. EGFR is frequently overexpressed, amplified, or mutated in various cancers, particularly non-small cell lung cancer (NSCLC), colorectal cancer, and glioblastoma.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
