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Human DcR3 Protein, His Tag

Human DcR3 Protein, His Tag

Catalog Number: S0A0225 Brand: Starter
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$200 USD
$200 USD
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Product Details

Product Specification


Species Human
Synonyms Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3 (DcR3), Decoy receptor for Fas ligand, M68, TNFRSF6B, DCR3, TR6
Accession O95407
Amino Acid Sequence

Protein sequence (O95407, Val30-His300, with C-His Tag) VAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH
Expression System HEK293
Molecular Weight Predicted MW: 31.4 kDaObserved MW: 35-37 kDa
Purity ＞90% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

TNFRSF6B is a soluble decoy receptor that lacks a transmembrane domain and cytoplasmic tail. It neutralizes three ligands—FasL, LIGHT, and TL1A—thereby inhibiting apoptosis, lymphocyte activation, and inflammation. Overexpression of TNFRSF6B is observed in various malignancies, including lung, colon, and pancreatic cancers, where it promotes immune evasion and tumor progression. It serves as a potential biomarker for cancer diagnosis and prognosis, and is being investigated as a therapeutic target for autoimmune diseases and cancer immunotherapy.

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Bioactivity

Immobilized Human TL1A/TNFSF15 Protein, hFc Tag (Cat. No. S0A4084) at 5 μg/mL (100 μL/well) can bind Human DcR3 Protein, His Tag with EC50 of 15.0-16.4 ng/ml.

SDS-PAGE

2μg（R: reducing conditions）