Immobilized Anti-CD20 Monoclonal Antibody (Rituximab) (Cat. No. S0B0570) at 10 μg/mL (100 μL/well) can bind Human C1q Protein, Flag Tag with EC50 of 0.60-0.74 μg/ml.
Human C1q Protein, Flag Tag
Human C1q Protein, Flag Tag
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$220 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Complement C1q |
| Accession | P02745、P02746、P02747 |
| Amino Acid Sequence | Protein sequence (P02745, Glu23-Ala245)EDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSAProtein sequence (P02746, Gln28-Ala253)QLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEAProtein sequence (P02747, Asn29-Asp245, with C-Flag Tag)NTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQTHQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMVGIQGSDSVFSGFLLFPD |
| Expression System | CHO Stable Cells |
| Molecular Weight | Predicted MW: 23.7 kDa (C1qA)&23.7 kDa (C1qB)&22.8 kDa (C1qC)Observed MW: 24, 28, 30 kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Complement C1q is the recognition subunit of the classical complement pathway. This ~460 kDa hexameric protein has a unique "bouquet of tulips" structure, with six globular heads connected to a collagen-like stalk. Each head binds to ligands such as antibody Fc regions (IgG1, IgG2, IgG3, and IgM), pentraxins, and apoptotic cells. This binding activates C1r and C1s proteases, triggering the complement cascade that drives opsonization, inflammation, and pathogen lysis. Beyond immunity, C1q is essential for clearing apoptotic cells and immune complexes, maintaining self-tolerance. C1q deficiency is strongly linked to systemic lupus erythematosus (SLE), highlighting its critical role in immune homeostasis.
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Bioactivity
SDS-PAGE
2 μg（R: reducing conditions; NR: non-reducing conditions）
