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Human BACE2 Protein, His Tag

Human BACE2 Protein, His Tag

Catalog Number: S0A0222 Brand: Starter
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Product Details

Product Specification


Species Human
Synonyms Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1 (ASP1; Asp 1), Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2), Down region aspartic protease (DRAP), Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, AEPLC, ALP56, ASP21
Accession Q9Y5Z0
Amino Acid Sequence

Protein sequence (Q9Y5Z0, Ala21-Pro466, with C-His Tag) APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEP
Expression System HEK293
Molecular Weight Predicted MW: 49.6 kDa Observed MW: 55 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Beta-secretase 2 (BACE2) is an aspartic protease encoded by a gene located on chromosome 21. It is expressed in various peripheral tissues and, to a lesser extent, in the central nervous system. Unlike its role in amyloid precursor protein (APP) processing, BACE2 primarily cleaves APP within the amyloid-beta domain, an action that may limit amyloid-beta peptide production. Its physiological functions extend to processes such as pancreatic beta-cell maintenance, skin pigmentation regulation, and skeletal muscle homeostasis. Research into BACE2 is also significant in the context of Down syndrome, due to the gene dosage effect associated with its chromosomal location.

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SDS-PAGE

2μg（R: reducing conditions）