2μg（R: reducing conditions）
Human ART1 Protein, His tag
Human ART1 Protein, His tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, ADP-ribosyltransferase C2 and C3 toxin-like 1 (ARTC1), Mono(ADP-ribosyl)transferase 1, CD296 |
| Accession | P52961 |
| Amino Acid Sequence | Protein sequence (P52961, Gln23-Asn294, with C-His tag) QSHPITRRDLFSQEIQLDMALASFDDQYAGCAAAMTAALPDLNHTEFQANQVYADSWTLASSQWQERQARWPEWSLSPTRPSPPPLGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTEALQLLGSGQRPPRCHQVFRGVHGLRFRPAGPRATVRLGGFASASLKHVAAQQFGEDTFFGIWTCLGAPIKGYSFFPGEEEVLIPPFETFQVINASRLAQGPARIYLRALGKHSTYNCEYIKDKKCKSGPCHLDN |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 32.1 kDa Observed MW: 38 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | with C-His tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
ART1 is a cell - surface protein. It belongs to the ADP - ribosyltransferase family and plays diverse roles in multiple cellular activities. In the immune system, CD296 is involved in T - cell activation and immune regulation, thereby influencing the intensity and direction of immune responses. For example, it may modulate the signaling pathways that determine whether T - cells proliferate, differentiate, or become activated to combat pathogens. In cancer research, abnormal expression of CD296 has been detected in some tumor cells. This aberrant expression is potentially linked to critical tumor - related processes such as cell proliferation, migration, and immune escape.
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