Immobilized Human ANGPTL3, His tag at 4 μg/mL (50 μL/well) can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 1.329-1.869 ng/ml.
Human ANGPTL3, His tag
Human ANGPTL3, His tag
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$45 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Angiopoietin-5 (ANG-5), ANGPT5 |
| Accession | Q9Y5C1 |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:25.4 kDa Actual:28-35 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/mg |
| Tag | with C-His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
ANGPTL3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), thereby increasing plasma triglyceride, LDL cholesterol and HDL cholesterol in mice and humans. In human, ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
