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Human ABP1/AOC1 Protein, His Tag

Human ABP1/AOC1 Protein, His Tag

Catalog Number: S0A0211 Brand: Starter
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Product Details

Product Specification


Species Human
Synonyms Diamine oxidase [copper-containing], Amiloride-binding protein, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase (KAO; KDAO), ABP, DAO
Accession P19801
Amino Acid Sequence

Protein sequence (P19801, Glu20-Val751, with C-His Tag) EPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
Expression System HEK293
Molecular Weight Predicted MW: 85.1 kDa Observed MW: 95 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

AOC1, or Amine Oxidase Copper Containing 1, is a key enzyme in histamine and polyamine metabolism. Primarily expressed in the intestine, placenta, and kidney, it catalyzes the degradation of histamine and oxidative deamination of polyamines like putrescine. This function is crucial for regulating local histamine levels, thereby influencing inflammatory and immune responses. AOC1 also plays a significant role in intestinal barrier function and mucosal protection. Its activity impacts various physiological and pathological processes, including allergies, asthma, and inflammatory bowel disease. Furthermore, AOC1 is a target for certain anti-inflammatory drugs, highlighting its therapeutic relevance. Genetic variations in AOC1 can affect enzyme activity and individual susceptibility to related disorders.

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SDS-PAGE

2μg（R: reducing conditions）