2μg (R: reducing condition).
HRSVA (strain A2) pre-fusion glycoProtein F0 His Tag Protein
HRSVA (strain A2) pre-fusion glycoProtein F0 His Tag Protein
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Product Details
Product Details
Product Specification
| Synonyms | Prefusion glycoprotein F0/pre-F protein (RSV) |
| Accession | ACO83301.1 |
| Amino Acid Sequence | Gln26-Leu513 with His Tag at the C-Terminus. Some mutations are introduced to stabilize the trimeric prefusion state of RSV Fusion glycoprotein. |
| Expression System | HEK293 |
| Molecular Weight | 55-72kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, PH7.4 |
| Reference | Capella C, Chaiwatpongsakorn S, Gorrell E, Risch ZA, Ye F, Mertz SE, Johnson SM, Moore-Clingenpeel M, Ramilo O, Mejias A, Peeples ME. Prefusion F, Postfusion F, G Antibodies, and Disease Severity in Infants and Young Children With Acute Respiratory Syncytial Virus Infection. J Infect Dis. 2017 Dec 12;216(11):1398-1406. |
Background
Human respiratory syncytial virus (HRSV) is the predominant etiological agent of acute lower respiratory tract infections in infants and demonstrates capacity for recurrent infections throughout life. The RSV fusion glycoprotein (RSV F) serves as the primary target for neutralizing antibodies in human sera. As a class I viral fusion protein, RSV F is synthesized as an inactive single-chain polypeptide that undergoes trimeric assembly.Membrane fusion is mediated through an irreversible conformational rearrangement from a metastable prefusion state to a stable postfusion conformation. Both structural states present distinct epitopes recognized by neutralizing antibodies. Notably, the postfusion RSV F conformation is currently under development as a promising vaccine candidate due to its structural stability and immunogenic properties
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SDS-PAGE
ELISA
Immobilized HRSVA (strain A2) pre-fusion glycoProtein F0 Protein, His Tag at 2.0μg/mL (100μL/well) can bind anti-RSV-pre F0 specific (siteØ epitope) Recombinant Human mAb (S-R376-2) with EC50 of 1.26-2.34 ng/mL.
