HGFR/c-MET Fc Chimera Protein, Human

Catalog Number: UA010829 Reactivity: Human Conjugation: Unconjugated Brand: UA BIOSCIENCE

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$276 USD

Size: 25μg 100μg 500μg

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Product Details

Product Specification

Species	Human
Synonyms	HGFR, c-MET, HGF/SF receptor, DFNB97, AUTS9, RCCP2, Hepatocyte growth factor receptor, Tyrosine-protein kinase Met
Accession	P08581
Amino Acid Sequence	Glu25-Thr932 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	34-48 kDa and 105-125 kDa (Reducing)
Purity	> 95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Neculai D. et al. (2013) Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 504: 172-176. McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73. Garcia S. et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-335. Socoteanu M P. et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-2994. Kong D S. et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.

Background

HGF R, also known as Met, is a glycosylated receptor tyrosine kinase that plays a pivotal role in epithelial morphogenesis and cancer development. It is synthesized as a single-chain precursor, which undergoes cotranslational proteolytic cleavage to form a mature HGFR. This mature receptor is a disulfide-linked dimer consisting of a 50 kDa extracellular alpha chain and a 145 kDa transmembrane beta chain. The extracellular domain (ECD) features a seven-bladed beta-propeller sema domain, a cysteine-rich PSI/MRS domain, and four Ig-like E-set domains. The cytoplasmic region contains the tyrosine kinase domain. HGFR is typically expressed by cells of epithelial origin, while HGF expression is limited to cells of mesenchymal origin.

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SDS-PAGE

1μg (R: reducing condition).

ELISA

Immobilized HGF Protein, Human (Cat. No. UA040194) at 2.0μg/mL (100μL/well) can bind HGFR/c-MET Fc Chimera Protein, Human (Cat. No. UA010829) with EC50 of 23.39-29.12ng/mL.

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HGFR/c-MET Fc Chimera Protein, Human