Her2 His Tag Protein, Cynomolgus
Her2 His Tag Protein, Cynomolgus
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$720.00 USD
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | Her2, ERBB2, CD340, HER-2/neu, MLN19, NEU, NGL, TKR1 |
| Accession | XP_005584091.2 |
| Amino Acid Sequence | Thr23-Thr652, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 85-95kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Krawczyk N. et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-4024. |
Background
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
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Bioactivity
Immobilized Her2 His Tag, Cynomolgus (Cat. No. UA010241) at 5μg/mL (100μL/well) can bind Anti-Human HER2(Trastuzumab) Monoclonal Antibody with EC50 of 2.00 -2.88ng/ ml.
Anti-Human HER2(Trastuzumab) Monoclonal Antibody captured on Protein A Biosenor, can bind Her2 His Tag, Cynomolgus (Cat. No. UA010241) with an affinity constant of 1.54 nM as determined in SPR assay.
SDS-PAGE
2μg (R: reducing conditions, N: non-reducing conditions).
