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HBS1L His Tag Protein, Human

HBS1L His Tag Protein, Human

Catalog Number: UA085083 Brand: UA BIOSCIENCE
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$2,000 USD
$2,000 USD
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Product Details

Product Specification


Species Human
Synonyms HBS1L, ERFS, HBS1
Accession Q9Y450
Amino Acid Sequence

Met1-Glu684 with His Tag at the N-Terminus
Expression System Baculovirus-InsectCells
Molecular Weight

70-100kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Liquid
Storage Buffer

50mM Tris, 150mM NaCl, PH7.5, 1mM DTT, 10%Glycerol
Stability & Storage

Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles.
Reference

1. Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. PLoS Genetics, 19(5), e1010765.
2. Hbs1l deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells. Disease Models & Mechanisms, 17(4), dmm050355.
3. Tumor suppressor collateral damage screens reveal mRNA homeostasis protein HBS1L as a novel vulnerability in ch9p21 driven FOCAD deleted cancer. (2025). Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1872(3), 119855.

Background

The HBS1L (HBS1 like translational GTPase) gene encodes a cytoplasmic protein belonging to the GTP-binding elongation factor family. The gene is located on human chromosome 6 and is expressed in multiple tissues, with the highest expression in heart and skeletal muscle. The HBS1L protein contains 685 amino acids and comprises four conserved domains, including the HBS1 N-terminus and multiple Elongation Factor Tu (EF-Tu)-like domains. The protein is predominantly localized in the cytoplasm but is also detected in nuclear bodies, cytosolic ribosomes, and extracellular exosomes.

Core Function: HBS1L is the GTPase component of the Pelota-HBS1L complex. This complex recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway, playing a critical role in ribosomal rescue. When ribosomes stall on mRNA, the HBS1L-PELO complex recognizes the stalled ribosome and promotes ribosome splitting, releasing the stalled translation complex.

Picture

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).