GPR153 Recombinant Rabbit mAb (S-4871-4)

GPR153 is an orphan receptor whose endogenous ligand and specific functions remain largely unknown, belonging to the rhodopsin-like class A family of G protein-coupled receptors (GPCRs). The protein features a typical seven-transmembrane α-helical structure, with three extracellular and three intracellular loops connecting the helices, and its predicted ligand-binding pocket is located in the core region formed by the transmembrane helices. A notable structural feature is that GPR153 substitutes the highly conserved DRY motif—essential for efficient G protein signaling in classical class A receptors—with an HRM motif in the third transmembrane helix (TM3), and contains an LPxFL motif (a variant of the NPxxY motif) at the end of TM7; this unique architecture may confer atypical signaling mechanisms. GPR153 shares a common evolutionary origin with GPR162 and is highly expressed in the central nervous system, particularly in the thalamus, cerebellum, and the arcuate nucleus of the hypothalamus—regions closely associated with sensory information processing, motor coordination, and the regulation of energy balance and feeding behavior. Studies have shown that it is also expressed in the mouse neocortex, striatum, substantia nigra, and other regions, suggesting a potential role in broader physiological processes such as decision-making and reward circuits. Furthermore, GPR153 expression has been detected in mouse ovaries, mammary glands, and various other tissues, and its protein has been localized to the cytoplasm and processes of astrocytes in the human brain; however, its precise physiological role in the central nervous system remains an active area of current research.