GM-CSF Protein, Human

Catalog Number: UA040101 Brand: UA BIOSCIENCE

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$156 USD

Size: 10μg 50μg 100μg 500μg 1mg

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Product Details

Product Specification

Species	Human
Antigen	GM-CSF
Synonyms	GM-CSF, Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-alpha, Molgramostin, Sargramostim Ala18-Glu144
Accession	P04141
Amino Acid Sequence	Ala18-Glu144
Expression System	E.coli
Molecular Weight	15kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 100mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Robertson S A. (2007) GM-CSF regulation of embryodevelopment and pregnancy. Cytokine Growth Factor Rev. 18(3-4): 287-298. 2.Waller E K. (2007) The role of sargramostim (rhGM-CSF)as immunotherapy. Oncologist. 12: 22-26. 3.Clive K S. et al. (2010) Use of GM-CSF as anadjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines.9(5): 519-525.

Background

Granulocyte-macrophagecolony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2(CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mastcells, natural killer cells, endothelial cells and fibroblasts that functionsas a cytokine. GM-CSF was first described as a growth factor that induces thedifferentiation and proliferation of myeloid progenitors in the bone marrow,which also has an important cytokine effect in chronic inflammatory diseases bystimulating the activation and migration of myeloid cells to inflammationsites, promoting survival of target cells and stimulating the renewal ofeffector granulocytes and macrophages. GM-CSF receptor is composed of one αchain and one β chain with low and high-affinity binding to GM-CSF,respectively, and the β chain is shared with IL-3 and IL-5 receptor. GM-CSFsignals via signal transducer and activator of transcription, STAT5. Inmacrophages, it has also been shown to signal via STAT3. The cytokine activatesmacrophages to inhibit fungal survival.