2μg (R: reducing condition).
Glycoprotein/GP RBD hFc chimera protein, Ebola virus-ACI28624
Glycoprotein/GP RBD hFc chimera protein, Ebola virus-ACI28624
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Product Details
Product Details
Product Specification
| Synonyms | Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007), Ebolavirus (subtype Bundibugyo, strain Uganda 2007) Envelope Glycoprotein 1 (GP1) Protein, GP, Envelope glycoprotein, GP (1,2) |
| Accession | ACI28624 |
| Amino Acid Sequence | Ile33 -Val308 with Human IgG1 Fc Tag at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 70-90kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & ＞90% by SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Wang, Han et al.Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.Cell.Volume 164;Issue 1:258 - 268 |
Background
Ebola virus glycoprotein (GP1), acting as a receptor-binding subunit, is crucial for the virus entry process. In the late stages of infection, GP1 downregulates key host cell surface molecules, including integrins such as ITGA1-6, which can disrupt cell adhesion and potentially lead to compromised vascular integrity.
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SDS-PAGE
SEC-HPLC
The purity of Glycoprotein/GP RBD hFc chimera protein, Ebola virus-ACI28624 is more than 90% determined by SEC-HPLC.
