IHC shows positive staining in paraffin-embedded human pancreas. Anti-GLP1R antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
GLP1R Recombinant Rabbit mAb (S-2200-163)
GLP1R Recombinant Rabbit mAb (S-2200-163)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | GLP1R |
| Synonyms | Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P43220 |
| Clone Number | S-2200-163 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500-1:1000 | Hu |
Background
GLP1R (Glucagon-like peptide-1 receptor) is a G protein-coupled receptor (GPCR) primarily expressed in pancreatic β-cells, as well as in the brain, heart, and gastrointestinal tract. It is activated by the incretin hormone GLP-1 (glucagon-like peptide-1), which is secreted by intestinal L-cells in response to nutrient ingestion. Upon activation, GLP1R stimulates glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and promotes satiety—making it a critical therapeutic target for type 2 diabetes mellitus and obesity. Notably, GLP1R agonists such as semaglutide and liraglutide have revolutionized metabolic disease management by mimicking endogenous GLP-1 action with enhanced stability and potency. Additionally, emerging evidence suggests neuroprotective and cardioprotective roles of GLP1R signaling, expanding its clinical relevance beyond glycemic control.
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Immunohistochemistry
Negative control: IHC shows negative staining in paraffin-embedded human tonsil. Anti-GLP1R antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
