GHR Fc Chimera Protein, Mouse

Growth hormone receptor (GHR), also known as growth hormone-binding protein (GHBP), is a single-pass type I transmembrane protein belonging to the cytokine receptor family. Its structure contains a typical fibronectin type-III domain and is predominantly expressed in the liver and skeletal muscle, while various isoforms are distributed in multiple tissues such as the kidneys and placenta. Upon binding to pituitary-derived growth hormone, this receptor activates the JAK2/STAT5 signaling pathway to regulate body growth and metabolism. The soluble GHBP, formed through proteolytic cleavage of the extracellular domain, serves as a circulating reservoir for growth hormone and negatively modulates signal transduction. Clinically, GHR gene defects are directly linked to multiple growth disorders, including severe growth hormone resistance such as Laron syndrome—characterized by growth retardation and impaired insulin-like growth factor I production—as well as idiopathic short stature and other inherited growth abnormalities. Thus, GHR is not only a key regulator of growth but also an important diagnostic and therapeutic target for related endocrine disorders.