GH Recombinant Rabbit mAb (SDT-234-270)
GH Recombinant Rabbit mAb (SDT-234-270)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | GH |
| Synonyms | Somatotropin; Growth hormone (GH; GH-N); Growth hormone 1; Pituitary growth hormone; GH1 |
| Immunogen | Recombinant Protein |
| Accession | P01241 |
| Clone Number | SDT-234-270 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against IGFBP3, IGF-1, FSH, hCG, LH, PRL, TSH |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Growth hormone is synthesized primarily by somatotropin in the anterior pituitary and stored in secretory granules. GH is a pleiotropic cytokine that exerts its biological effects by binding to transmembrane GH receptors present in many cell types. hGH stimulates hepatic insulin-like growth factor-1 and mobilizes fatty acids from fat deposits to the liver. GH can act directly or indirectly through IGF-1 on B cells, T cells, NK cells, macrophages, and neutrophils to exert immunomodulatory activity. Insufficient secretion of hGH results in dwarfism in children, and excessive secretion results in gigantism in children or acromegaly in adults.
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