GDF-6/BMP-13 Protein, Human

Catalog Number: UA040365 Brand: UA BIOSCIENCE

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$100 USD

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Product Details

Product Specification

Species	Human
Synonyms	Growth/differentiation factor 6; GDF-6; Bone morphogenetic protein 13 (BMP-13); Growth/differentiation factor 16;
Accession	Q6KF10
Amino Acid Sequence	Thr336-Arg455
Expression System	E.coli
Molecular Weight	15-16 kDa (Reducing)
Purity	>95% by SDS-PAGE.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	4mM HCl
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in 4mM HCl after rapid centrifugation.
Stability & Storage	·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Reference	Nature. 1994 Apr 14;368(6472):639-43. Development. 1999 Mar;126(6):1305-15.

Background

Growth differentiation factor 6 (GDF-6), also known as bone morphogenetic protein 13 (BMP-13), is a member of the transforming growth factor-beta (TGF-β) superfamily of cytokines that plays a critical role in skeletal development and joint maintenance. In humans, GDF-6 is expressed in various tissues, including cartilage, bone, and synovium, and is involved in regulating chondrogenesis, osteogenesis, and joint homeostasis. GDF-6 exerts its biological effects by binding to specific cell surface receptors, such as the BMP receptors, leading to the activation of downstream signaling pathways, including Smad and non-Smad pathways. Through its signaling activities, GDF-6 promotes the differentiation of mesenchymal stem cells into chondrocytes and osteoblasts, as well as the maintenance of cartilage integrity and joint function. GDF-6 is considered a key regulator of skeletal development and joint health, with implications for musculoskeletal disorders and regenerative medicine.