GDF-2/BMP-9 Protein, Mouse

Catalog Number: UA040582 Brand: UA BIOSCIENCE

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$225 USD

Size: 10μg 50μg 100μg 500μg 1mg

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Product Details

Product Specification

Species	Mouse
Synonyms	Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9 (BMP-9)
Accession	Q9WV56
Amino Acid Sequence	Ser319-Arg428
Expression System	CHO
Molecular Weight	12-13 kDa (Reducing)
Purity	>95% by SDS-PAGE.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	4mM HCl
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in Reconstitution Buffer after rapid centrifugation.
Stability & Storage	·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Reference	Developmental Dynamics. 2022;251(1):178-197. Genes & Diseases. 2019;6(3):201-223.

Background

Growth differentiation factor 2 (GDF-2), also known as bone morphogenetic protein 9 (BMP9), is a secreted ligand of the transforming growth factor-beta (TGF-β) superfamily. The mouse Gdf2 gene is located on chromosome 14 and encodes a protein that signals primarily through the type I activin receptor ALK1 (ACVRL1). GDF-2/BMP9 was originally identified from fetal mouse liver cDNA libraries and is highly expressed in the liver and lungs of postnatal mice.

In the industrial and translational sectors, GDF-2/BMP9 is recognized as one of the most potent osteogenic factors for inducing mesenchymal stem cell differentiation, with applications in bone tissue engineering, fracture healing, cartilage formation, and spinal fusion. Its potent anti-angiogenic activity has also been explored therapeutically, including in age-related macular degeneration via the ALK1-Fc fusion protein ACE-041.