2μg (R: reducing condition, N: non-reducing condition).
GDF-15/MIC-1 Protein, Mouse
GDF-15/MIC-1 Protein, Mouse
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$195 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1 |
| Accession | Q9Z0J7 |
| Amino Acid Sequence | Ser189-Ala303 |
| Expression System | CHO |
| Molecular Weight | 24-25 kDa (Non-Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 4mM HCl |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in Reconstitute Buffer after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Review Front Immunol. 2020 May 19;11:951. |
Background
Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is highly expressed in placenta and is expressed at lower levels in kidney, pancreas, prostate and colon. Similarly to other TGF-beta family proteins, GDF-15 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. GDF-15 has been studied to have a wide range of biological functions in physiology and pathology, especially in aging, cancer, and metabolic processes.
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SDS-PAGE
RP-HPLC
>95% as determined by RP-HPLC.
ELISA
Immobilized GDF-15 Protein, Mouse (Cat. No. UA040564) at 2.0μg/mL (100μL/well) can bind GFRAL Fc Chimera Protein, Human (UA011250) with EC50 of 3.0-3.5 ng/mL.
