Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1cells. The IC50 for this effect is 12 ng/ml.
GDF-11/BMP-11 Protein, Human/Mouse/Rat
GDF-11/BMP-11 Protein, Human/Mouse/Rat
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$160 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11 |
| Accession | O95390 |
| Amino Acid Sequence | Asn299-Ser407 |
| Expression System | CHO |
| Molecular Weight | 12-13 kDa (Reducing) |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 4mM HCl |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in Reconstitution Buffer after rapid centrifugation. |
| Stability & Storage |
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles. |
| Reference |
Nature Communications. 2025;16(1):6534. Reviews in the Neurosciences. 2026;37(7):787-798. |
Background
Human Growth Differentiation Factor 11 (GDF11), also known as Bone Morphogenetic Protein 11 (BMP11), is a secreted ligand belonging to the TGF-β superfamily, encoded by the GDF11 gene on chromosome 12q13.2. While its primary and best-established function lies in regulating anterior-posterior axial skeletal patterning and neurogenesis during embryonic development, its role in adult physiology—particularly regarding aging and regeneration—remains highly controversial and actively debated. In academia, GDF11 is a focal point of research across several domains: developmental biology (somitogenesis, neural stem cell regulation), cardiovascular biology (contradictory roles in cardiac hypertrophy and myocardial infarction), and neurology (neurogenesis and cognitive decline).
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
