Flow cytometric analysis of CD324 expression on F9 (Mouse embryonal carcinoma epithelial cell). Cells from the F9 were stained with either FITC Rat IgG1, κ Isotype Control (black line histogram) or SDT FITC Rat Anti-Mouse/Human CD324 Antibody (red line histogram) at 2 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Rat Anti-Mouse/Human CD324 Antibody (S-R650)
FITC Rat Anti-Mouse/Human CD324 Antibody (S-R650)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD324 |
| Synonyms | Cadherin-1; CAM 120/80; Epithelial cadherin (E-cadherinImported); Uvomorulin; CDHE; UVO; CDH1 |
| Location | Cytoplasm, Endosome, Cell membrane |
| Accession | P12830、P09803 |
| Clone Number | S-R650 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B80190 |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | F9 |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Hu, Ms |
Background
CD324, also known as E-cadherin or cadherin-1, is a calcium-dependent cell adhesion protein that plays a crucial role in maintaining epithelial tissue integrity and regulating cell proliferation, differentiation, and survival. It is a member of the cadherin superfamily and is widely expressed on the cell surface of most epithelial tissues. The extracellular domain of CD324 facilitates homophilic binding between adjacent cells, while its cytoplasmic domain interacts with the actin cytoskeleton through catenins. This protein is essential for epithelial cell cohesion and acts as an invasion suppressor, with its loss often indicating high tumor aggressiveness in cancer.
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