Flow cytometric analysis of Mouse CD41 expression on C57BL/6 mouse platelets. C57BL/6 mouse platelets were stained with FITC Rat IgG1, κ Isotype Control (Black line histogram) or SDT FITC Rat Anti-Mouse CD41 Antibody (Red line histogram) at 5μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Rat Anti-Mouse CD41 Antibody (S-R690)
FITC Rat Anti-Mouse CD41 Antibody (S-R690)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD41 |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; Itga2b |
| Location | Membrane |
| Accession | Q9QUM0 |
| Clone Number | S-R690 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse platelets |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD41, also known as integrin αIIb or platelet glycoprotein IIb, is a crucial protein involved in platelet aggregation and hemostasis. It is encoded by the ITGA2B gene and forms a heterodimer with integrin β3 (CD61) to create the fibrinogen receptor on platelets. This receptor is essential for platelet aggregation, as it binds soluble fibrinogen and other ligands like plasminogen, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Mutations in the CD41 gene can lead to Glanzmann thrombasthenia, a bleeding disorder characterized by prolonged bleeding after injury. CD41 is also used as a marker to identify platelets, megakaryocytes, and hematopoietic progenitor cells.
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