Flow cytometric analysis of mouse CD192 expression on BALB/c mouse bone marrow. BALB/c mouse bone marrow were stained with Brilliant Violet 421™ Rat Anti-Mouse CD11b Antibody and either FITC IgG2b, k Isotype Control (left panel) or FITC Rat Anti-Mouse CD192 Antibody (right panel) at 0.5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Rat Anti-Mouse CD192 Antibody (S-R731)
FITC Rat Anti-Mouse CD192 Antibody (S-R731)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD192 |
| Synonyms | C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; JE/FIC receptor; MCP-1 receptor; Cmkbr2 |
| Location | Cell membrane |
| Accession | P51683 |
| Clone Number | S-R731 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Isotype Control | FITC Rat IgG2b Isotype Control (S-R486) |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 0.25μg per million cells in 100μl volume | Ms |
Background
CD192, also known as CCR2, is a seven-transmembrane, G-protein-coupled receptor that belongs to the beta chemokine receptor family. It is primarily expressed on monocytes, macrophages, basophils, dendritic cells, and some T cells. CD192 acts as a receptor for several chemokines, including monocyte chemoattractant protein-1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13. This receptor plays a crucial role in mediating monocyte chemotaxis and is involved in various inflammatory responses, such as the recruitment of monocytes into tissues during atherosclerosis, rheumatoid arthritis, and tumor formation. Additionally, CD192 has been implicated in the pathogenesis of certain cancers, where it controls the recruitment of activated macrophages that can either promote tumor cytotoxicity or inhibit tumor growth.
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