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FITC Rat Anti-Mouse CD122 (IL-2Rβ) Antibody (S-4060)

FITC Rat Anti-Mouse CD122 (IL-2Rβ) Antibody (S-4060)

Catalog Number: S0B8551 Application: FCM Reactivity: Mouse Conjugation: FITC Brand: Starter
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Product Details

Product Specification


Host Rat
Antigen CD122 (IL-2Rβ)
Synonyms Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; Il2rb
Location Cell membrane
Accession P16297
Clone Number S-4060
Antibody Type Rat mAb
Isotype IgG2b,k
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse splenocytes
Purification Protein G
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Ms

Background

CD122, also known as interleukin-2 receptor beta (IL-2Rβ), is a 75 kDa type I transmembrane glycoprotein that serves as the shared signaling subunit for the IL-2, IL-7 and IL-15 cytokine receptors; upon ligand binding it heterodimerizes with IL-2Rγc to activate JAK1/JAK3–STAT5, PI3K–AKT and MAPK pathways that drive survival, proliferation and cytolytic programs in T, B, NK and memory T cells, making it a central regulator of both lymphocyte homeostasis and potent target for immunotherapies against cancer and autoimmunity.

Picture

FC

Flow cytometric analysis of Mouse CD122 (IL-2Rβ) expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with APC Rat Anti-Mouse CD49b antibody and either FITC Rat IgG2b, κ Isotype Control (Left panel) or SDT FITC Rat Anti-Mouse CD122 (IL-2Rβ) Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.