Flow cytometric analysis of Mouse NK1.1 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Phycoerythrin Rat Anti-Mouse CD49b antibody and either FITC Mouse IgG2a, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Mouse NK1.1 Antibody (Right panel) at 0.25 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Mouse Anti-Mouse NK1.1 Antibody (S-R480)
FITC Mouse Anti-Mouse NK1.1 Antibody (S-R480)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | NK1.1 |
| Synonyms | Killer cell lectin-like receptor subfamily B member 1B allele A; CD161 antigen-like family member B; Lymphocyte antigen 55b (Ly-55b); NKR-P1 34; Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B); CD161b; Ly55b; Nkrp1b; Klrb1b |
| Location | Membrane |
| Accession | P27812 |
| Clone Number | S-R480 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume | Ms |
Background
NK1.1, also known as CD161 or KLRB1, is a type II transmembrane C-type lectin-like receptor that is primarily expressed on the surface of natural killer (NK) cells and certain subsets of T cells, including both CD4+ and CD8+ T cells. It is particularly prevalent on adult T cells with a "memory" antigenic phenotype. The expression of NK1.1 is associated with the cytotoxic function of CD16+ NK cells, and its ligation with its ligand LLT1 can inhibit NK cell cytotoxicity and cytokine secretion. This marker is commonly used in the identification and study of NK cells, especially in mouse models, where it is a key indicator for distinguishing NK cells from other immune cell populations.
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