Flow cytometric analysis of Mouse CX3CR1 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD11b antibody and either FITC Mouse IgG2a, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Mouse CX3CR1 Antibody (Right panel) at 0.25 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Mouse Anti-Mouse CX3CR1 Antibody (S-R597)
FITC Mouse Anti-Mouse CX3CR1 Antibody (S-R597)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CX3CR1 |
| Synonyms | CX3C chemokine receptor 1; C-X3-C CKR-1; mCX3CR1; Fractalkine receptor |
| Location | Cell membrane |
| Accession | Q9Z0D9 |
| Clone Number | S-R597 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume | Ms |
Background
CX3CR1, also known as the fractalkine receptor, is a unique member of the CX3C chemokine receptor family. It specifically binds to its sole ligand, CX3CL1 (fractalkine), to mediate immune cell chemotaxis and adhesion. This receptor plays a crucial role in various physiological and pathological processes, including immune response, neuroinflammation, neurodegenerative diseases, and cancer. The interaction between CX3CR1 and CX3CL1 is highly specific, which presents advantages for drug development targeting this receptor, although no drugs have been successfully marketed yet. Additionally, cholesterol molecules have been found to play a key role in the activation and signal transduction of CX3CR1, influencing its conformation and function. Understanding the molecular mechanisms of CX3CR1 and its ligand recognition provides valuable insights for developing targeted therapies for related diseases.
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