Flow cytometric analysis of CD11b expression on human peripheral blood cells. Human peripheral blood cells were stained with Brilliant Violet 421™ Mouse Anti-Human CD14 and either FITC Mouse IgG1, k Isotype Control (left panel) or SDT FITC Mouse Anti- Human CD11b Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Mouse Anti-Human CD11b Antibody (ICRF44)
FITC Mouse Anti-Human CD11b Antibody (ICRF44)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD11b |
| Synonyms | Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CR3A; ITGAM |
| Location | Cell membrane |
| Accession | P11215 |
| Clone Number | ICRF44 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B1529 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD11b, also known as integrin alpha M, is a transmembrane glycoprotein that pairs with CD18 to form the Mac-1 integrin, also referred to as complement receptor type 3 (CR3). It is predominantly expressed on the surface of myeloid cells, including monocytes, neutrophils, macrophages, and microglia. CD11b plays a crucial role in mediating cell adhesion and migration, facilitating the interaction between immune cells and their targets. It is involved in phagocytosis, the process by which cells engulf and eliminate foreign particles or debris. Additionally, CD11b acts as a receptor for complement C3bi, mediating complement-coated particle uptake, and it binds to various ligands such as intercellular adhesion molecules (ICAMs) and fibrinogen, contributing to cell-mediated cytotoxicity, chemotaxis, and immune cell activation.
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