FITC Mouse Anti-Human C1qR1/CD93 Antibody (VIMD)

C1qR1, also known as CD93, is a type I transmembrane glycoprotein initially identified as a receptor for complement C1q; however, its function as a genuine C1q receptor remains controversial, as its binding to C1q is considered to occur only under non-physiological conditions. Structurally, the protein contains an N-terminal C-type lectin domain and five epidermal growth factor (EGF)-like domains, and is expressed on various cell types, including monocytes, neutrophils, and endothelial cells. Nevertheless, current studies have demonstrated that C1qR1/CD93 participates in multiple physiological processes, including cell-cell adhesion, regulation of phagocytosis of opsonized particles by myeloid cells, and clearance of apoptotic cells, as well as playing an important role in plasma cell differentiation and the maintenance of long-lived plasma cells in the bone marrow.