Flow cytometric analysis of Mouse CD48 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Armenian hamster IgG Isotype Control (Black line histogram) and SDT FITC Armenian hamster Anti-Mouse CD48 Antibody (Red line histogram) at 5μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
FITC Armenian hamster Anti-Mouse CD48 Antibody (S-R654)
FITC Armenian hamster Anti-Mouse CD48 Antibody (S-R654)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | Mouse CD48 |
| Synonyms | CD48 antigen; BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2 (SLAMF2); Signaling lymphocytic activation molecule 2; sgp-60; Bcm-1 |
| Location | Cell membrane |
| Accession | P18181 |
| Clone Number | S-R654 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD48 (also known as SLAMF2) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and a member of the signaling lymphocyte activation molecule (SLAM) family. It is expressed on various immune cells, including T cells, B cells, and natural killer (NK) cells. CD48 interacts with several ligands, such as CD2 and CD244 (2B4), to mediate immune cell adhesion, activation, and signaling. These interactions play crucial roles in T cell activation, NK cell cytotoxicity, and immune synapse formation. In disease contexts, CD48 expression is often upregulated in inflammatory conditions and certain cancers, such as acute myeloid leukemia (AML), where it may influence immune evasion and tumor progression. Additionally, CD48 has been identified as a potential biomarker and therapeutic target in autoimmune diseases, allergic conditions, and cancer immunotherapy.
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