Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells.The EC50 for this effect is less than 100ng/ml.
FGF-19 Protein, Human
FGF-19 Protein, Human
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$156 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Antigen | FGF-19 |
| Synonyms | FGF-19 |
| Accession | O95750 |
| Amino Acid Sequence | Leu25-Lys216 |
| Expression System | E.coli |
| Molecular Weight | 24kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 200mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Rabia Bag Soytas, Veysel Suzan, Pinar Arman. Association of FGF-19 and FGF-21 levels with primary sarcopenia. Geriatr Gerontol Int. 2021 Oct;21(10):959-962.Epub 2021 Aug 17. |
Background
Fibroblast Growth Factors (FGFs) are polypeptides with diverse activities in development and physiology. The mammalian Fgf family can be divided into the intracellular Fgf11/12/13/14 subfamily (iFGFs), the hormone-like Fgf15/21/23 subfamily (hFGFs), and the canonical Fgf subfamilies, including Fgf1/2/5, Fgf3/4/6, Fgf7/10/22, Fgf8/17/18, and Fgf9/16/20. FGF-19 is secreted from ileal enterocytes similar to a hormone. Endocrine derived hormone FGF-19 has recently emerged as a potential target for the treatment of metabolic diseases. In recognition of the skeletal muscle as an important metabolic organ, it is considered that FGF-19 may also have a role in muscle metabolism and may be a new factor with promising value in the treatment of sarcopenia.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
ELISA
Immobilized FGF-19 Protein, Human (Cat. No. UA040086) at 10.0μg/mL (100μL/well) can bind Klotho β Protein, Human (Cat. No. UA040050) with EC50 of 0.35-0.57 μg/mL.
