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FGF-12 Protein, Human

FGF-12 Protein, Human

Catalog Number: UA040116 Brand: UA BIOSCIENCE
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$124 USD
$124 USD
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Product Details

Product Specification


Species Human
Antigen FGF-12
Synonyms Fibroblast growth factor homologous (FHF-1), Myocyte-activating factor, FGF12B
Accession P61328-2
Amino Acid Sequence

Met1-Thr181
Expression System E.coli
Molecular Weight

21kDa
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized Powder
Storage Buffer

20mM PB, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1. Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1463-73.

Background

Fibroblast growth factor 12 (FGF-12), also known as fibroblast growth factor homologous factors (FHF), is cytosolic proteins that is homologous to fibroblast growth factors but is not secreted. FGF12 modulates both cardiac Na+ and Ca+ channel by binding to the conserved proximal part of the C-terminal domain of voltage-gated sodium channels Nav1.5. However, a single missense mutation in FGF12-B (Q7R-FGF12) reduced binding to the NaV1.5 C-terminus, yielding a Brugada Syndrome phenotype.

Picture

SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).