ERCC2 Recombinant Rabbit mAb (S-4403-3)

ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2), also known as XPD (Xeroderma Pigmentosum group D), is a multifunctional ATP-dependent 5'→3' DNA helicase that serves as the core catalytic subunit of the transcription factor IIH (TFIIH) complex, playing an irreplaceable dual role in DNA repair and transcriptional regulation. In the nucleotide excision repair (NER) pathway, ERCC2 utilizes its helicase activity to locally unwind the double helix at DNA damage sites, providing spatial access for the excision and repair of damaged fragments. Simultaneously, as an essential component of TFIIH, it participates in RNA polymerase II-mediated transcription initiation, assisting in unwinding the DNA double strand at gene promoter regions to initiate transcription. Consequently, mutations or functional deficiencies in ERCC2 simultaneously affect both DNA repair and transcription—two fundamental life processes—leading to multiple severe diseases, most notably Xeroderma Pigmentosum, in which patients exhibit extreme UV sensitivity and dramatically increased risk of skin cancer due to impaired DNA repair capacity. Additionally, its mutations are also associated with other rare disorders such as Cockayne Syndrome and Trichothiodystrophy. Given its central role in maintaining genomic stability and regulating gene expression, ERCC2 gene polymorphisms have been extensively studied as potential biomarkers for prognosis assessment in various cancers (such as lung cancer and melanoma) as well as for predicting sensitivity to platinum-based chemotherapy drugs.