Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 20ng/ml.
Epiregulin Protein, Human
Epiregulin Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Epiregulin; EPR |
| Accession | O14944 |
| Amino Acid Sequence | Val63-Leu108, with N terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 33 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Gene.2006 Jan 17;366(1):2-16. Epub 2005 Dec 27. |
Background
Epiregulin is a member of the epidermal growth factor (EGF) family of proteins that plays a crucial role in cell signaling and regulation. It acts as a ligand for the epidermal growth factor receptor (EGFR) and is involved in various cellular processes, including cell proliferation, survival, migration, and differentiation. Epiregulin exerts its cellular activities by binding to EGFR and activating downstream signaling pathways, such as the MAPK/ERK and PI3K/Akt pathways, which regulate gene expression and cellular responses. The dysregulation of epiregulin signaling has been implicated in cancer development, metastasis, and resistance to therapy, highlighting its importance in cellular homeostasis and disease progression.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
SEC-HPLC
>95% as determined by SEC-HPLC.
