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EPCR/PROCR His Tag Protein, Human

EPCR/PROCR His Tag Protein, Human

Catalog Number: UA016098 Brand: UA BIOSCIENCE
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$180 USD
$180 USD
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Product Details

Product Specification


Species Human
Synonyms CD201, APC receptor, CCCA, CCD41
Accession Q9UNN8
Amino Acid Sequence

Ser18-Ser210 with His Tag at the C-Terminus
Expression System HEK293
Molecular Weight 35-40kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Wang H, March L, Jackson CJ, Cross M, Xue M. EPCR in Wound Healing: Mechanisms of Action and Therapeutic Potential. Cells. 2026 Mar 22;15(6):567.
2. Song H, Li Q, Gui X, Fang Z, Zhou W, Wang M, Jiang Y, Geng A, Shen X, Liu Y, Zhang H, Nie Z, Zhang L, Zhu H, Zhang F, Li X, Luo F, Zhang H, Shen W, Sun X. Endothelial protein C receptor promotes retinal neovascularization through heme catabolism. Nat Commun. 2025 Feb 13;16(1):1603.
3. Chambers SEJ, Guduric-Fuchs J, Pedrini E, Bertelli PM, Charoensuk C, Peixoto E, Pathak V, Alhamdan HI, Xie R, Krasnodembskaya A, Lechner J, Stitt AW, Medina RJ. Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity. Angiogenesis. 2025 May 23;28(3):30. 

Background

EPCR (PROCR/CD201/activated protein C receptor) is a type I transmembrane N-glycosylated glycoprotein structurally related to the MHC class I/CD1 superfamily, featuring an extracellular domain with two α-helices and eight β-strands forming a hydrophobic lipid-binding groove. It is highly expressed on endothelial cells of arteries and veins in heart and lung, as well as on various stem/progenitor cells. Functionally, EPCR enhances protein C activation to APC by the thrombin-thrombomodulin complex, regulating coagulation; it also mediates cytoprotective signaling via PAR1, promoting cell proliferation, angiogenesis, and anti-inflammatory responses. A soluble form (sEPCR) is released by metalloproteases such as ADAM17. Clinically, EPCR represents a promising therapeutic target—its inhibition attenuates pathological retinal neovascularization, while APC-EPCR axis activation shows efficacy in wound healing, sepsis, and retinal protection, with non-anticoagulant APC variants being developed to minimize bleeding risks.

Picture

SDS-PAGE

1μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of EPCR/PROCR His Tag Protein, Human is more than 95% determined by SEC-HPLC.